Dr. Stuart Warden, PhD, PT, FACSM

Biography

Appointments

• Assistant Professor and Director of Research, Department of Physical Therapy, Indiana University School of Health and Rehabilitation Sciences
• Assistant Professor, Department of Anatomy and Cell Biology, Indiana University School of Medicine
• Assistant Professor, Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University-Purdue University Indianapolis (IUPUI)
• Fellow (Lecturer level), Centre for Health, Exercise and Sports Medicine, School of Physiotherapy, The University of Melbourne (Australia)

Education

• Research Postdoctorate, Orthopaedics, Indiana University School of Medicine, Indianapolis, IN (2004)
• Clinical Postdoctorate, Sports Medicine, Australian Institute of Sport, Australia (2001)
• Ph.D., Physical Therapy, University of Melbourne, Australia (2001)
• Bachelor of Physiotherapy (Honors), Physical Therapy, University of Melbourne, Australia (1997)

Awards

• Finalist, Indy’s ‘Best & Brightest’ Awards (Health & Life Sciences), Junior Achievement of Central Indiana and KPMG (2006, 2007, 2008 & 2009)
• Fellow, American College of Sports Medicine (2007)
• Outstanding Faculty Award, Indiana University–Purdue University Indianapolis (2007)
• New Investigator Award (Clinical Sciences), American College of Sports Medicine (2006)
• Excellence Award in Research, School of Health and Rehabilitation Sciences, Indiana University (2006 & 2007)
• AIMM-ASBMR John Haddad Young Investigator Award, Advances in Mineral Metabolism-American Society of Bone Mineral Research John Haddad Young Investigators Meeting (2005)
• ASBMR-Harold Frost Young Investigator Award, Sun Valley Workshop on Skeletal Tissue Biology (2005)
• ASICS Award for Best Young Investigator, Australian Sports Medicine Federation Fellows Awards (2005)
• New Investigator Recognition Award, Orthopaedic Research Society (2004)
• Young Investigator Award and Plenary Oral Presentation, American Society of Bone Mineral Research (2003)
• C.J. Martin Fellowship, National Health and Medical Research Council, Australia (2002–2004)
• Finalist, Young Australian of the Year Awards (Finalist in Health & Life Sciences), Commonwealth Minister for Youth Affairs Career Achievement Category (2002)
• Alice L. Jee Memorial Young Investigator Travel Award, 32nd International Sun Valley Hard Tissue Workshop (2002)
• Postgraduate Scholarship in Physiotherapy, Australian Institute of Sport (2001)
• Young Investigator Travel Awards, Australian and New Zealand Bone and Mineral Society (1999-2000)
• Melbourne Research Scholarship, University of Melbourne (1998-2001)
• Freda Kimpton Prize in Anatomy, School of Physiotherapy, University of Melbourne (1997)
• Dean’s Honors List, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne (1995-1997)

Editorial Board Membership

Dr Warden is a member of the editorial boards of the following international journals: British Journal of Sports Medicine; Journal of Orthopaedic and Sports Physical Therapy; Journal of Science and Medicine in Sport.

Manuscript Reviewer

Dr Warden has been called upon to peer-review manuscripts submitted to the following journals:

• Acta Pharmacologica Sinica
• Australian Journal of Physiotherapy
• American Journal of Physiology—Regulatory, Integrative and Comparative Physiology
• American Journal of Sports Medicine
• Annals of Biomedical Engineering
• Archives of Oral Biology
• BioMedical Engineering OnLine
• BMC Musculoskeletal Disorders
• BMC Physiology
• Bone
• British Journal of Nutrition
• British Journal of Sports Medicine
• Calcified Tissue International
• Canadian Journal of Physiology and Pharmacology
• Clinical Drug Investigation
• Clinical Journal of Sports Medicine
• Connective Tissue Research
• European Journal of Clinical Investigation
• European Journal of Physical and Rehabilitation Medicine
• Experimental Biology and Medicine
• Expert Review of Endocrinology and Metabolism
• Gender Medicine
• Hormone and Metabolic Research
• International SportMed Journal
• Journal of Applied Physiology
• Journal of Biomechanical Engineering
• Journal of Biomedical Science and Engineering
• Journal of Bone and Mineral Research
• Journal of Clinical Densitometry
• Journal of Dental Research
• Journal of Musculoskeletal and Neuronal Interactions
• Journal of Orthopaedic and Sports Physical Therapy
• Journal of Orthopaedic Research
• Journal of Science and Medicine in Sport
• La revue de Médecine Vétérinaire
• Medical Letter in Drugs and Therapeutics
• Medicine and Science in Sport and Exercise
• Nature Clinical Practice Rheumatology
• Osteoporosis International
• Pharmacogenetics and Genomics
• Physical Therapy
• Physical Therapy in Sport
• Physician and Sportsmedicine
• Physiotherapy
• Scandinavian Journal of Medicine and Science in Sport
• Sports Health
• Sports Medicine
• Ultrasound in Medicine and Biology

Grant Reviewer

Dr Warden has been called upon to peer-review research grant proposals submitted to the following national and international funding agencies:

• Austrian Science Fund (Fonds zur Förderung der wissenschaftlichen Forschung [FWF])
• Biomedical Research Council, Agency for Science, Technology and Research, Singapore
• Canadian Institutes of Health Research
• Indiana Spinal Cord and Brain Injury Fund, Indiana State Department of Health
• Leaders Opportunity Fund, Canadian Foundation of Innovation
• Medical Research Council of the United Kingdom
• Merit Review and Evaluation Board, Rehabilitation Research and Development Service, Department of Veteran Affairs
• National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
• National Science Foundation
• National University of Singapore
• Netherlands Organisation for Health Research and Development
• Physiotherapy Research Foundation, Australian Physiotherapy Association
• Research Grants Council of Hong Kong
• Research Support Funds Grants, Indiana University
• Thrasher Research Fund
• United States Army Research and Materiel Command.

Clinical and Teaching Experience

As an avid sportsman, Dr Warden’s clinical and teaching experience is primarily in sports medicine. He worked for a number of years in sports medicine clinics and provided physical therapy coverage for numerous amateur sporting teams in Australia. In addition, he has provided physical therapy services at many sporting events, including the Sydney 2000 Olympic Games and Australian University Games. As an instructor, Warden specializes in musculoskeletal injuries and their treatment, and he co-ordinates the Musculoskeletal Practice Pattern (P541 and P622) courses in the IU DPT program.

Research Interests

Research is a major component of Dr Warden’s work, where he investigates normal and abnormal functioning of the musculoskeletal system. He has research interests in musculoskeletal responses to exercise and injury, the musculoskeletal effects of pharmaceutical agents (especially anti-inflammatories and anti-depressants), and the efficacy of physical therapy interventions for musculoskeletal conditions. Common conditions investigated in Dr Warden’s research include osteoporosis, complete bone fractures, stress fractures, tendon overuse injuries, and ligament sprains.

Current Research Support

NIH-NIAMS (R15 AR056858)
Long-term skeletal effects of exercise during growth
Role: Principal investigator (1.5 academic months)
$231,000

NIH-NIAMS (R01 AR052018)
The function of neurotransmitters in bone biology
Role: Subcontract co-investigator (3 summer months) [PI-Bliziotes (Oregon Health and Science University)]
$1,480,725 (IU subcontract $608,000)

National Space Biomedical Research Institute (MA01604)
Extent, causes, and countermeasures of impaired fracture healing in hypogravity
Role: Subcontract principal investigator (1 academic month) [PI-Midura (Cleveland Clinic)]
$1,789,968 (IU subcontract $338,472)

Department of Defense
Secreted Wnt antagonists in disuse-induced osteoporosis
Role: Co-investigator (1 academic month) [PI-Robling (IU School of Medicine)]
$1,062,982

NIH-NICHD (R01 HD057126)
Supplemental vitamin D and functional outcomes in early adolescence
Role: Subcontract co-investigator (0.5 academic months) [PI-Lewis (University of Georgia)]
$1,076,127

Outside Interests

Dr Warden enjoys most sports and can often be found at the golf course or gardening with his wife, young son and dog.

Publications

Castillo AB, Alam I, Tanaka SM, Levenda J, Li J, Warden SJ and Turner CH: Effects of low amplitude, broad-frequency vibration on cortical bone formation in mice. Bone 2006;39:1087-1096

Chu TM, Warden SJ, Turner CH and Stewart RL: Segmental bone regeneration using a load-bearing biodegradable carrier of bone morphogenetic protein-2. Biomaterials 2007;28:459-67

Crossley KM, Thancanamootoo K, Metcalf BR, Cook JL, Purdam CR and Warden SJ: Clinical features of patellar tendinopathy and their implications for rehabilitation. Journal of Orthopaedic Research 2007;25:1164-1175

Li J, Waugh LJ, Hui SL, Burr DB and Warden SJ: Low-intensity pulsed ultrasound and a non-steroidal anti-inflammatory drug have opposing effects during stress fracture repair. Journal of Orthopaedic Research 2007;25:1559-1567

Robling AG, Warden SJ, Schultz KL, Beamer WG and Turner CH: Genetic effects on bone mechanotransduction in congenic mice harboring bone size and strength quantitative trait loci Journal of Bone and Mineral Research 2007;22:984-991

Sawakami K, Robling AG, Ai M, Pitner ND, Liu D, Warden SJ, Li J, Maye P, Rowe DW, Duncan RL, Warman ML and Turner CH:The WNT co-receptor LRP5 is essential for skeletal mechanotransduction, but not for the anabolic bone response to parathyroid hormone trea

Warden SJ, Avin KG, Beck EM, DeWolf ME, Hagemeier MA and Martin KM: Knee ligament healing is accelerated by low-intensity pulsed ultrasound and delayed by a non-steroidal anti-inflammatory drug. American Journal of Sports Medicine 2006;34:1094-1102

Warden SJ, Burr DB and Brukner PD: Stress fractures: pathophysiology, epidemiology and risk factors. Current Osteoporosis Reports 2006;4:103-109

Warden SJ, Creaby MW, Bryant AL and Crossley KM: Stress fracture risk factors in women soccer players and their clinical implications. British Journal of Sports Medicine 2007;41(Suppl. 1):i38-i43

Warden SJ, Fuchs RK, Castillo AB, Nelson IR and Turner CH: Exercise when young provides lifelong benefits to bone structure and strength. Journal of Bone and Mineral Research 2007;22:251-9

Warden SJ, Fuchs RK, Kessler CK, Avin KG, Cardinal RE and Stewart RL: Ultrasound produced by a conventional therapeutic ultrasound unit accelerates fracture repair. Physical Therapy 2006;86:1118-1127

Warden SJ, Hinman RS, Watson MA, Avin KG, Bialocerkowski AE and Crossley KM: Patellar taping and bracing for the treatment of chronic knee pain: a systematic review and meta-analysis. Arthritis and Rheumatism: Arthritis Care and Research 2008;59:78-83

Warden SJ, Kiss ZS, Malara FA, Ooi AB, Cook JL and Crossley KM: Comparative accuracy of magnetic resonance imaging and ultrasonography in confirming clinically diagnosed patellar tendinopathy. American Journal of Sports Medicine 2007;35:427-36

Warden SJ, Saxon LK, Castillo AB and Turner CH: Knee ligament mechanical properties are not influenced by estrogen or its receptors. American Journal of Physiology: Endocrinology and Metabolism 2006;290:E1034-E1040

Warden SJ: Animal models for the study of tendinopathy. British Journal of Sports Medicine 2007;41:232-40

Warden SJ: Breaking the rules for bone adaptation to mechanical loading. Journal of Applied Physiology 2006;100:1441-1442