Pulmonary Physiology Lab
- To evaluate exercise as therapy for patients with pulmonary arterial hypertension (PAH), a devastating disease of progressive pulmonary vascular remodeling for which there is no cure and presently no effective treatment. The goal is to define the physiological, biochemical and molecular adaptations that result from exercise in PAH animals, and in humans with PAH, so that exercise may be prescribed in a manner that optimizes beneficial outcomes and minimizes distress, cost, and potentially detrimental effects.
- To develop the novel use of 2-photon microscopy of fresh human skin biopsies for in-vivo investigation of diseases of epithelial transport, such as cystic fibrosis.
- To further develop and utilize intravital microscopy, the imaging of living organ tissue maintained in its native physiological environment, to document in real time vascular and immune responses at the lung’s alveolar level in rodent models of pulmonary disease.