Mary Beth Brown, PT, PhD
Education & Training
Undergraduate: Bachelor of Arts 1992 Lenoir-Rhyne College, Hickory, NC, Department of Exercise Science
Graduate: Master of Science in Physical Therapy 1995 University of Miami, Coral Gables, FL, School of Medicine, Department of Physical Therapy
Graduate: Doctor of Philosophy 2009 Georgia Institute of Technology, Atlanta, GA, School of Applied Physiology; Mentors: Dr. Mindy Millard-Stafford, Dr. Nael McCarty (Emory)
Postdoctoral: 2010-2011 Indiana University School of Medicine, Indianapolis, IN, Division of Pulmonary and Critical Care Medicine; Mentor: Dr. Irina Petrache
Research & Clinical Interests
Research & Clinical Interests
My research passion is to study exercise as a therapeutic intervention for diseased and disabled populations. Exercise is an underutilized medicine, in part because so little data exists to assist practitioners in its appropriate prescription for specific patient groups. My current research charge is to evaluate exercise for patients with pulmonary vasculature disease. Much of my focus has been on exercise in pulmonary arterial hypertension (PAH), a devastating disease of progressive pulmonary vascular remodeling for which there is no cure and presently no effective treatment. My clinical and animal studies aim to define the physiological and biochemical consequences and functional outcomes following acute and chronic exercise in PAH, to permit much needed optimization of exercise prescription for patients.
With the help of outstanding graduate and undergraduate students, we have generated mechanistic data of acute and chronic exercise responses in four different rat models of pulmonary hypertension (PH). Our rat exercise interventions include individually- prescribed treadmill programs as well as voluntary wheel running, and our endpoints include cardiopulmonary exercise testing, echocardiography, invasive hemodynamic measurements, and biochemical and histological assays of harvested tissue. By far the most important and exciting work of my lab to date is determining how to measure pulmonary and systemic pressures during treadmill exercise in my rat model utilizing state-of-the-art implantable telemetry. While technically challenging, obtaining hemodynamic measures via implantable telemetry provides significant strength over the existing method of non-survival invasive measures under intubation and general anesthesia. Most importantly however, telemetry hemodynamics has permitted my laboratory, very recently, to be the first to obtain serial measurements of pulmonary pressures during exercise in an animal model. These data are both novel to the field and significantly clinically relevant, since exercise intolerance is a hallmark and not completely understood symptom of PAH. The ability to now perform these telemetric measurements in rats has accelerated my lab toward the objective of optimizing exercise parameters for PH, since responses such as pulmonary pressure spikes and heightened heart wall stress can now be monitored in real-time during experimental interventions. Finally, our lab is testing some of our findings from animals studies in clinical investigations. For instance, we have recently completed a clinical study of mild intensity aerobic exercise training plus daily L-arginine supplementation in PAH.
Honors & Awards
Awarded to Dr. Brown for Research
2017 ACSM’s President’s Cup- top student poster at the Annual Meeting of the American College of Sports Medicine- awarded to Gary Long for research completed with Dr. Brown.
2016 New Investigator Award- American College of Sports Medicine
2015 American Physical Therapy Association, Cardiopulmonary Section research award for best poster presentation at the Combined Sections Meeting 2015
2014 Emerging Excellence in Research—Faculty Award- School of Health and Rehabilitation Sciences
2014 Cardiovascular & Pulmonary Poster Research Award- Combined Sections Meeting of the American Physical Therapy Association
2009 Carl V. Gisolfi Memorial Award, American College of Sports Medicine, for research: “Mechanisms and Implications of Sodium Loss in Sweat During Exercise in the Heat for Cystic Fibrosis Patients and Healthy Individuals”
2009 The Howard R. Thranhardt Award by The American Academy of Orthotists and Prosthetists (AAOP) for research: “Physiological Responses of Amputees during Treadmill Exercise in Running-Specific Prostheses Compared to Traditional Prostheses and to Matched Non-Amputee Runners.”
2008 Doctoral Student Research Award, Southeast Region of the American College of Sports Medicine: “Relationship of Heart Rate to Oxygen Consumption is Similar for Amputee and Non-Amputee Runners.”
Awarded to Dr. Brown’s students for research
2018 Cardiovascular & Pulmonary Section Platform Presentation Research Award- Combined Sections Meeting of the American Physical Therapy Association- awarded to DPT students Spenser Studebaker and Kelly Jay for research completed with Dr. Brown.
2018 Best Masters Student Research Poster, Midwest Regional Chapter meeting of the American College of Sports Medicine- awarded to Ashley Troutman for research completed with Dr. Brown.
- 2017 Best Graduate Research Poster, Midwest Regional Chapter meeting of the American College of Sports Medicine- awarded to Gary Long for research completed with Dr. Brown.
- 2017 2nd place Platform Presentation, Indiana chapter conference of the American Physiological Society- awarded to Gary Long, a Health Sciences
PhDstudent, for research completed with Dr. Brown.
- 2016 Cardiovascular & Pulmonary Section Poster Research Award- Combined Sections Meeting of the American Physical Therapy Association- awarded to DPT student Attie Kempf for research completed with Dr. Brown.
- 2016 Cardiovascular & Pulmonary Section Platform Presentation Research Award- Combined Sections Meeting of the American Physical Therapy Association- awarded to DPT students Jeremy Graber and Brett Gladish for research completed with Dr. Brown.
- 2016 Top Platform Presentation, Indiana chapter conference of the American Physiological Society- awarded to Gary Long, a Health Sciences
PhDstudent, for research completed with Dr. Brown.
- 2015 Top Undergraduate Research Poster, Indiana chapter conference of the American Physiological Society- awarded to Tsungai Chingombe, an IUPUI student, for research completed with Dr. Brown as part of an internship through the Undergraduate Research Opportunities Program.
- 2013 Top Undergraduate Research Poster, Indiana chapter conference of the American Physiological Society- awarded to Richard Gaidoo, an Ivy Tech student, for research completed with Dr. Brown as part of an internship through the Bridges to Baccalaureate Program.
- 2012 Top Undergraduate Research Award, IUPUI Research Day- awarded to Tsungai Chingombe, a junior in the Department of Chemistry, for research completed with Dr. Brown as part of an internship through the Undergraduate Research Opportunities Program.
- 2011 Best Undergraduate Research Poster, Midwest Regional Chapter meeting of the American College of Sports Medicine- awarded to Tsungai Chingombe, a sophomore in the Department of Chemistry, for research completed with Dr. Brown as part of an internship through the Bridges to Baccalaureate Program.
P531: Clinical Physiology, Pathophysiology, and Pharmacology-1 (6 cr.)
P535: Clinical Physiology, Pathophysiology, and Pharmacology-2 (6 cr.)
(asterisk indicates mentored student)
- Dmitry V. Zaretsky, Hannah Kline, Maria V. Zaretskaia, Mary Beth Brown, Pamela J. Durant, Nathan J. Alves, Daniel E. Rusyniak. Disinhibiting neurons in the dorsomedial hypothalamus delays the onset of exertional fatigue and exhaustion in rats exercising in a warm environment. Accepted March 20th, 2018; Brain Research.
Mary Beth Brown, *Attie Kempf, *Catherine Collins, *Gary Long, *Shikha Gupta, Yaron Hellman, Vincent Wong, Mark Farber, Tim Lahm. A Prescribed Walking Regimen plus Arginine Supplementation Improves Function and Quality of Life for Patients with Pulmonary Arterial Hypertension: A Pilot Study. Pulmonary Circulation 2017; 8(1) 1–12. DOI: 10.1177/2045893217743966
- Brown MB, Neves E, *Long G, *Novack R, *Graber J, *Gladish B, *Owens M, *Wiseman A, Fisher A, Presson R, Petrache I, Kline J, Lahm T.
High IntensityInterval Training but not Continuous Training Reverses Right Ventricular Remodeling and Dysfunction in a Rat Model of Pulmonary Arterial Hypertension; Am J Physiol Reg Int Comp Physiol. doi:10.1152/ajpregu.00358.2016 Online October 26, 2016.
- *Neves E, Brown MB, Zaretskaia M, Rezania S, Goodwill A, McCarthy B, Persohn S, Territo P, Kline J. Chronic embolic pulmonary hypertension caused by pulmonary embolism and vascular endothelial growth factor inhibition; Am J Pathol. In press Feb 4, 2017. PMID: 28183533
- Lahm T, *Frump A, Albrecht A, Fisher A, Cook T, Jones T, Yakubov B, Whitson J, Fuchs R, Liu A, Chesler N, Brown MB. 17β-Estradiol Mediates Superior Adaptation Of Right Ventricular Function To Acute Strenuous Exercise In Female Rats With Severe Pulmonary Hypertension, Am J Physiol Lung Cell Mol Physiol. Jun 2016,
ajplung.00132.2016; DOI: 10.1152/ajplung.00132.2016.
- Brown MB, *Chingombe TJ, *Zinn AB, *Reddy JG, *Novack RA, Cooney SA, Fisher AJ, Presson RG, Lahm T, Petrache I. Novel assessment of hemodynamic kinetics with acute exercise in a rat model of pulmonary arterial hypertension. Exp. Physiol. 2015 Apr 13.
doi: 10.1113/EP085182. [Epub ahead of print].
- Frump AL, Goss KN, Vayl A, Albrecht M, Fisher AJ, Tursunova R, Fierst J, Whitson J, Cucci AR, Brown MB, Lahm T. Estradiol Improves Right Ventricular Function In Rats With Severe Angioproliferative Pulmonary Hypertension: Effects Of Endogenous And Exogenous Sex Hormones. Am J Physiol Lung Cell Mol Physiol. 2015 May 1;308(9):L873-90,
- Goss KN, Cucci AR, Fisher AJ, Albrecht M, Frump AL, Tursunova R, Gao Y, Brown MB, Petrache I, Tepper RS, Ahlfeld SK & Lahm T (2015). Neonatal Hyperoxic Lung Injury Favorably Alters Adult Right Ventricular Remodeling Response to Chronic Hypoxia Exposure. Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15;308(8)
:L797-806. doi: 10.1152/ajplung.00276.2014.
- Zaretsky D; Brown MB; Zaretskaia M; Durant P; Rusyniak D. The Ergogenic Effect of Amphetamine. Temperature 2014; 1(3):242-247.
- Brown, MB; Hunt, WR; Noe, J; Rush, N; Schweitzer, K; *Leece, T; Moldobaeva, A; Wagner, E; Dudek, S; Poirier, C; Presson, R; Gulbins, E; Petrache, I. Loss of CFTR impairs lung endothelial cell barrier function and increases susceptibility to microvascular damage from cigarette smoke. Pulm Circ 2014;4(2):260-268.
- Lockett AD, Brown MB, Santos-Falcon N, Rush NI, Oueini H, et al. (2014) Active Trafficking of Alpha 1 Antitrypsin across the Lung Endothelium. PLoS ONE 9(4): e93979.
- Lahm, Tim; Albrecht, Marjorie; Fisher, Amanda; Selej, Mona; Patel, Neel; Brown, Jordan; Justice, Matthew; Brown, MB; Van Demark, M; Trulock, K; Dieudonne, D; *Reddy, J; Presson, R; Petrache, I. 17-Beta Estradiol Attenuates Hypoxic Pulmonary Hypertension Via Estrogen Receptor-Mediated Effects. Am J Respir Crit Care Med. 2012 May 1;185(9):965-80.
- Schweitzer KS, Hatoum H, Brown MB, Gupta M, Justice MJ,
BeteckB, Van Demark MJ, Gu Y, Presson RG Jr, Hubbard WC, Petrache I. Mechanisms of lung endothelial barrier disruption induced by cigarette smoke: roleof oxidative stress and ceramides. Am J Physiol Lung Cell Mol Physiol. 2011 Dec;301(6) :L836-46.
- Brown, MB, McCarty, N, Millard-Stafford, M. High sweat [Na+] in cystic fibrosis and healthy individuals does not diminish thirst during exercise in the heat. American Journal of Physiology-Regulatory, Integrative, and Comparative Physiology 2011 Oct; 301(4)
- Brown MB, Presson R (co-1st authors), Fisher A, Sandoval R, Dunn K, Lorenz K, Delp E, Salama P, Molitoris B, Petrache I. Two-photon imaging within the murine thorax without respiratory and cardiac motion artifact. American Journal of Pathology. 2011 Jul;179(1):75-82.
- Brown, MB, Vincent, K, Millard-Stafford, M, Pollack, B, McCarty, N. Low abundance of sweat duct chloride channel CFTR in both healthy and cystic fibrosis athletes with exceptionally salty sweat during exercise in the heat. American Journal of
Physiology- Regulatory, Integrative, and Comparative Physiology. 2011 Mar; 300(3) :R605-15.
- Schweitzer KS, Johnstone BH, Garrison J, Rush NI, Cooper S, Traktuev DO, Feng D, Adamowicz JJ, Van Demark M, Fisher AJ, Kamocki K, Brown MB, Presson RG Jr, Broxmeyer HE, March KL, Petrache I. Adipose stem cell treatment in mice attenuates lung and systemic injury induced by cigarette smoking. American Journal of Respiratory and Critical Care Medicine
, .2011 Jan 15;183(2):215-25.
- Kram, R., Grabowski, A., McGowan, C., Brown, MB., McDermott, W., Beale, M., Herr, H. Counterpoint: Artificial Limbs Do Not Make Artificially Fast Running Speeds Possible. Journal of Applied Physiology, 2010 Apr;108(4):1012-4.
- Weyand, P., Bundle, M., McGowan, C., Grabowski, A., Brown, MB., Kram, R., Herr, H. The fastest runner on artificial legs: different limbs, similar function? Journal of Applied Physiology, 2009 Sep; 107(3):903-11.
- Brown, MB., Millard-Stafford, M., *Allison, A. Run prostheses permit energy costs similar to non-amputee. Medicine and Science in Sports and Exercise, 2009 May; 41(5):1080-7.