Center for Translational Musculoskeletal Research

Musculoskeletal health refers to the health and welfare of structures associated with the body’s bones, muscles, and joints, including ligaments, tendons and other specialized connective tissues. While much research has investigated the normal and abnormal physiology of these structures and efficacy of interventions, it is clear more needs to be done. Musculoskeletal diseases are the second greatest cause of disability affecting more than 1.7 billion people worldwide. This burden has increased by 45% over the last 20 years and will continue to do so unless action is taken.

  • Mission

    The mission of the Center for Musculoskeletal Research (CTMR) is to advance health by performing studies into the normal, and abnormal form and functioning of the musculoskeletal system. The Center is particularly interested in bridging the gap between basic science and clinical research by translating findings from preclinical (cell- and animal-based models) studies to clinical populations, and vice versa.

  • Objectives

    The main objectives of the CTMR are to:

    • Investigate normal and abnormal form and functioning of the musculoskeletal system throughout the lifespan by:
      • Developing and/or investigating preclinical (in vitro and animal based) models of the musculoskeletal system
      • Conducting clinical studies of the musculoskeletal system
      • Translating research findings garnered from preclinical models to clinical populations, and vice versa
    • Foster collaboration and facilitate interdisciplinary research between investigators interested in the musculoskeletal system
    • Promote student participation in musculoskeletal research
  • Laboratories

    Research within the CTMR occurs in laboratories:

    • Human Structure and Function Laboratory
    • Small Animal Structure and Function Laboratory
    • Soft Tissue Treatment and Ultrasound Imaging Laboratory
  • Funding

    Studies within the CTMR have been supported by:

    • National Institute of Arthritis and Musculoskeletal and Skin Disorders
    • National Institute of Child Health and Human Development
    • National Science Biomedical Research Institute
    • Department of Defense
    • Massage Therapy Foundation
    • Indiana Clinical and Translational Sciences Institute
    • IUPUI Office of the Vice Chancellor for Research